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Instead, it has been studied primarily for its potential role in regulating fat metabolism

doi: 10.1111/exd.12906

Any perceived weight loss benefits typically relate to the correction of deficiency symptomssuch as fatigue and low moodwhich may indirectly improve an individual's capacity for physical activity and dietary adherence

In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]