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Draw volume by dose at 8 mg/mL (16 mg vial + 2 mL) Dose 1 mg Volume 0.13 mL U-100 units ~13 units Dose 2 mg Volume 0.25 mL U-100 units 25 units Dose 4 mg Volume 0.50 mL U-100 units 50 units For a 10 mg vial with 2 mL water (5 mg/mL): 2 mg = 0.4 mL (40 units) and 4 mg = 0.8 mL (80 units)

The mean pain score for the BPI (three patients had a total of five data points missing) and FAS (three patients had a total of one data point each missing) decreased to a similar extent for both ARA 290 and the placebo group (Table 2), which were not significantly different from each other