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The COMBO-DN study was a large, double-blind, randomized clinical trial that compared the efficacy and safety of high-dose monotherapy versus combination therapy with duloxetine and pregabalin in patients with DPN who had not responded to standard doses [126]

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Transcriptomic analysis of purified iSPNs at the pre-symptomatic stage has uncovered the early molecular changes driving their vulnerability in the absence of TrkB signalling