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683 Remarkably, the work summarized here on the superoxide dismutases (SODs) and ribonucleotide reductases (RNRs) reveal that cambialism and more generally metalloenzyme paralogs have evolved in enzymes that catalyze more restrictive chemistry, where a change in oxidation state and even access to high-valent intermediates, is involved

10.1126/sciadv.adr8243 200 HuangH.XuH.LuoQ.HeJ.LiM.ChenH.et al