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A diagnosis of cytoplasmic vacuolation of hepatocytes will typically be an acceptable descriptive diagnosis

Restoring GSH level is a good tool to deal with the above states but direct oral supplementation with GSH is not very efficient because of its poor absorption and because of its hydrolytic degradation in the digestive system

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Summary of Key Points Bottom line: Taking Vitamin C while on Accutane is widely considered safe and may help reduce skin irritation, provided you choose a bioavailable oral form rather than an acidic topical one