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No but the stack logic is strongest when combined with a GLP-1 agonist creating a caloric deficit

Importantly, AOD-9604 did not produce any of the adverse effects associated with growth hormone therapy, including glucose intolerance, insulin resistance, edema, joint pain, or tissue growth abnormalities

An important limitation of the DSIP literature is that much of the human research was published decades ago, primarily during the 1980s and early 1990s