J Biol Chem (1997) 272(15):102605
Moreover, different methods of measuring the outcomes, lack of sample calculation, and small samples (n) may influence the quality and generate biases in disseminating systematic reviews based on animal experimentation, compromising extrapolation to humans [17, 30]
A representative study of community-dwelling elderly found that higher glutathione levels were associated with higher levels of physical health, fewer illnesses, and higher levels of self-rated health.15 As might be expected, then, GSH status has been found to parallel telomerase activity, an important indicator of lifespan.16 This depletion of GSH also shows up as progressive loss of mitochondrial function due to accumulation of damage to mtDNA.17 The ability of animal species to protect their mtDNA is directly proportional to longevity.18 GGT as Measure of Glutathione Need GGT (gamma-glutamyl transferase) is upregulated in proportion to the need for glutathione such as for the detoxification of POPs.19 It provides the rate-limiting cysteine through a catabolic salvage pathway. Increases in GGT correlate with many diseases: metabolic syndrome, both fatal and nonfatal coronary heart disease (CHD) events, atherosclerosis, fatty liver, diabetes, cancer, hypertension, and carotid intima-media thickness.2022 Of particular note, these are elevations of GGT within the supposedly normal range
In conclusion, increased oxidative stress may play an important role in the pathogenesis of refractory epilepsy
