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Its earliest clinical applications were in oral and maxillofacial surgerydentists and oral surgeons in the 1980s and 1990s began using PRP to accelerate bone and soft tissue healing following dental implants, extractions, and reconstructive jaw procedures

Some animal and early-phase studies noted elevated inflammatory cytokines (IL-6, TNF-) at higher doses, though clinical relevance in humans at therapeutic doses remains unclear

Rhythmic NAD + oscillates circadian clock Organisms have developed internal clocks as a timekeeping mechanism to collaborate biological processes with the exogenous environmental and endogenous factors

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