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In terms of systemic infection and prognosis, although the polymorphism of Dectin-1/CARD9 is not consistently associated with the susceptibility to Candida bloodstream infection, the responses of the heterozygous Y238X carriers to cytokines in vitro are weakened, which may affect the inflammatory regulation and prognosis of severe infections (Rosentul et al., 2011)

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A randomized, placebo-controlled, double-blind clinical trial with parallel design was conducted on 73 healthy overweight or obese women

Indeed, the prognoses of patients carrying NRF2-positve cancers are significantly poor (Shibata et al., 2008b