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Determination of the optimal dose of cagrilintide dose in chow-fed and HFD-fed WT mice In the first study, the acute response to three doses of cagrilintide were compared to the vehicle in WT 129S2 chow-fed mice

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In certain embodiments, any controlled release otic formulation or composition described herein increases the exposure of a therapeutic agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition