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My over active imagination is conjuring up pictures of anaphylactic shocks, even though I have had the B12 injections from doctor before

Those who undergo GI surgery, like removal of intestines or gastric bypass, may also have difficulty with B12 absorption (4, 5)

Historically, a complex bidirectional communication system between the gastrointestinal tract, its microbiota, and the CNScomprising neural, hormonal, and immune pathwayshas been recognized and termed the MGB axis (51)