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Both models excluding the subjects with ESRD occurring within 3 years (adjusted HR 1.989, 95% CI 1.7462.256) and 5 years (adjusted HR 1.944, 95% CI 1.6232.328) demonstrated a significant association between RA and the risk of ESRD, suggesting the least likelihood of reverse causation

A fourfold or higher relative risk sounds alarming, yet the absolute chance for any one patient stays low

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