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In patients with baseline dactylitis or enthesitis, treatment with certolizumab pegol resulted in statistically greater improvement compared with the placebo group

The peptide exhibits consistent efficacy in models of acute and chronic injury regardless of administration route (intraperitoneal, oral, or local application), a unique characteristic distinguishing it from other growth factors that typically require localized delivery with carrier systems

Furthermore, it alleviates depressive-like behaviors and exhibits neuroprotective properties in other CNS diseases

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