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Saratale RG, Benelli G, Kumar G, Kim DS, Saratale GD

Cosmetic outcomes reported for topical use Pickart and Margolinas reviews summarize controlled cosmetic studies in which topical GHK-Cu formulations were reported to tighten loose skin, improve elasticity, increase skin density and firmness, reduce fine lines and wrinkles, reduce photodamage, and reduce hyperpigmentation, alongside increased keratinocyte proliferation

Dysregulation of the mitochondrial ACE2/MrgE/NO axis may have a significant effect on the neurodegenerative processes of dopaminergic neurons, where mitochondrial dysfunction and oxidative stress may have a substantial impact [76]

Therefore, a key element in improving cosmetic formulations is research into the skin permeation of compounds with therapeutic effects