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The most common adverse effects from the SURMOUNT trials include: Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-25% of participants Constipation: 13-17% of participants Vomiting: 8-12% of participants Decreased appetite: 10-15% of participants Most of these effects are mild to moderate and occur primarily during dose escalation periods

The current standard surveillance program includes multiple random biopsies obtained throughout the colon at regularly scheduled intervals

: : BPC-157

Animal housing, husbandry, and experiments were conducted as per the National Institutes of Health guide for the care and use of laboratory animals (NIH Publications No