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The copper coordination chemistry of GHK-Cu enables controlled cellular copper delivery while preventing the formation of reactive oxygen species characteristic of free copper toxicity, with the peptide's binding affinity (log K = 16.1) positioning it perfectly within the physiological copper transport hierarchy to facilitate controlled metal transfer to enzymatic targets including lysyl oxidase (essential for collagen cross-linking) and superoxide dismutase (critical for antioxidant defense)

The CPP-ELP-H1 reduced the tumor volume by 80% and doubled the mean survival time

The issue is the expectation, not the peptide

Others get inside the cell and play a more direct role in the chemistry