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In particulate, 36 PCOS patients who did bariatric surgery achieved weight loss as well as regulate androgen level and ovarian volume and that was confirmed by ultrasound in a study conducted in 2021

For both cohorts, animals were deeply anesthetised 90 min later (pentobarbital 100 mg/kg, i.p) and transcardially perfused with cold 0.1 M of phosphate buffer (PB) for 1.5 min followed by 4% of paraformaldehyde (PFA) in PB for 2.5 min

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Figure 5 Whether or not GDC treatment results in modulation of intracellular cAMP levels, cAMP was measured in undifferentiated Caco-2/HT29-MTX cells following treatment with 0, 0.5, 0.8 and 1 mM GDC (Figure 5B)