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In addition, human umbilical vein endothelial cells (HUVEC) also exhibited an upregulation of eNOS and enhanced Akt phosphorylation, which plays an important role in vasodilation

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thaliana , the gene expression of GLR homolog3.5 (AtGLR3.5, constituting Ca 2+ channels) was significantly up-regulated in germinating seeds, which in turn increased cytosolic Ca 2+ concentration, eventually stimulating seed germination via counteracting the inhibiting effect of ABA (Kong et al., 2015)

In summary, expect gradual improvements rather than an immediate surge