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There are several limitations in the current study

(2023) 'FolateMethionine Cycle Disruptions in ASD Patients and Possible Interventions: A Systematic Review', *Genes*, 14(3), p

A placebo-controlled trial shows that 6mg of supplemental melatonin decreases inflammatory markers (TNF-alpha, IL-6, and CRP) in obese women.[ref] A meta-analysis of a bunch of studies found that melatonin consistently reduces CRP and IL-6 in people with metabolic syndrome.[ref] Several studies have shown that supplemental melatonin (along with diet) increases weight loss.[ref][ref] Diabetes: Adding melatonin with exercise cures insulin resistance, hypertension, and fatigue in an animal model of diabetes.[ref] But what about humans

When serum B12 falls in the gray zone, methylmalonic acid testing is recommended to clarify whether a functional deficiency exists