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Exposure to Tenofovir, Emtricitabine, Ritonavir, and Darunavir resulted in a 37% increase in beta-galactosidase staining and shortening of telomere length to more than half of the length of controls, indicating accelerated NPC senescence in response to ART exposure

[15] Animal studies in vivo An in vivo study in aging mice found that epitalon treatment significantly reduced the incidence of chromosomal aberrations, both for wild-type mice and for mice characterized by an accelerated aging phenotype, which is consistent with increases in telomere length

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3.2.2 Ferroptosis and parkinsons disease PD is the second most prevalent NDD, characterized by the degeneration and loss of dopaminergic neurons in the substantia nigra of the midbrain