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18 Estrogen-only therapy (for women without a uterus) was associated with lower breast cancer incidence and mortality Estrogen plus progestin therapy showed a slight increase in breast cancer incidence, but no increase in breast cancer mortality Additional reviews examining hormone therapy in women with a history of breast cancer found no increase in breast cancer mortality , with only one study showing increased local recurrence, not distant spread or death

While more human trials on injectable forms are ongoing, its safety profile remains strong

Lau JL, Dunn MK