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it is supported by robust, large-scale observational data from the patient community itself

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10.1016/j.molstruc.2013.01.049 [DOI] [Google Scholar] Gao T

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558,559 However, SIRT1 and SIRT2 are generally reduced in ALS primary motor cortex while they are upregulated in the spinal cord in human post-mortem tissues

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