Proceedings of the National Academy of Sciences of the United States of America , 109 (23), 89838
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Research suggests that larazotide may help to promote actin rearrangement in a way that leads to enhanced adherence of cells to one another, thereby reducing the ability of fistulas to penetrate tissues that would otherwise not be permeable
Interestingly, lactylation of NUSAP1 at lysine 34 prevents its protein degradation and increases its expression in PDAC cells, establishing an NUSAP1-LDHA-glycolysis-lactate loop that promotes PDAC metastasis
