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1988 Oct 10;238(2):343-6., Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ Disease Management and Clinical Outcomes 1(4):136-141 July 1998, Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study Arch Pharm Res

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13 Hyperuricemia is known to stimulate the renin-angiotensin system and impair endothelial nitric oxide release, which collectively lead to renal vasoconstriction and increased blood pressure