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The absence of IGF-1 pathway activation is also consistently observed across experimental systems, reinforcing its value in studies requiring separation of metabolic and growth-related signaling pathways

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Early observations suggest that it may interact with signaling pathways involved in maintaining cellular structure and function in preclinical models

838 This conundrum of the inactive dimeric IcmF was ultimately solved when it was shown that in the presence of GMPPCP, IcmF oligomerizes into filamentous chains, thus creating the active MeaB-like dimer between IcmF dimers within the filament (Figure 43B)