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Higher-end translational estimates may extend beyond these figures, but without human trials, higher exposure does not equal better outcomes

While the sample is small (6 patients), it represents an important step in the evidence chain: moving from laboratory proof-of-concept to human clinical testing

Research suggests that calcium deficiency may be a common concern for women with PCOS, although the exact relationship between calcium status and insulin resistance remains uncertain [141]

Factors like the severity of your arthritis, your age, and your activity level will influence which treatment is best for your individual needs