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Hepatocyte growth factor induces DNA synthesis and proliferation of vascular endothelial cells through the activation of ERK and STAT3 (Dong et al., 2001

However, in the normal physiological conditions follicular fluid NO seems to be synthesized from granulosa cells by endothelial NO synthase, since in isolated human follicular cells at least 90% of cells are granulosa cells even though macrophages and lymphocytes are present as well

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Unlike GHK-Cu, which occurs naturally in the body, AHK-Cu is lab-made and specifically designed to target hair follicles