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Moreover, a phenotypic study on human primary macrophages and stellate cells suggested that AXA1125 can inhibit lipopolysaccharide (LPS)-induced TNF- expression in M1 macrophages and increase the secretion of anti-inflammatory chemokine C-C motif ligands by M2 macrophages, as well as reduced Pro-C3 and HSP47 expression in HSC
On the contrary, lower GSH levels were also recorded among males of Group B, which might be related to several factors, including more rapid utilization against increased oxidative stress caused by testosterone and sex-dependent regulation of GSH metabolism
There is significant evidence that androgens promote adaptation to oxidative stress [68] and our data showing heightened ROS levels in BM-PCa (i.e., micromolar range H 2 O 2 production) (Fig
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