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The clinical potential of this approach is underscored by the approval of istradefylline in Japan and the United States as an adjunct therapy for PD patients experiencing motor fluctuations, representing the most advanced A 2A receptor antagonists in clinical development [480482]

Noise exposure induced a chronic tinnitus percept as measured by startle reflex inhibition In the use of the PPI paradigm as a behavioral assay, we collected data from 34 companion controls to construct a 95% confidence interval (CI) for the mean tinnitus index score, which served as the normative reference for estimating tinnitus

Experimental studies suggest that DSIP influences the release of stress-related hormones such as adrenocorticotropic hormone and cortisol analogs in animal systems, indicating a role in feedback regulation of neuroendocrine stress pathways [4]

Moreland & Cannella, 2026)