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In addition, there was upregulation in the expression of the proinflammatory cytokine Tnf and genes involved in the integrated stress response ( Atf3 , Atf5 , Ddit3 and Dele1 ) and reduced expression of the adipokine Adipoq

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Notably, non-internalized NPs like pristine SiO 2 NPs [452] and LaVO 4 :Eu 3+ NPs [459] can still trigger eryptosis, relying on Ca 2+ signaling, which can be mediated by their direct influence on Piezo1 channels

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