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doi: 10.3389/fphar.2014.00196 Received 05 July 2014 Accepted 06 August 2014 Published 26 August 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Anastassios Papageorgiou, University of Turku, Finland

If you experience any unexpected symptoms whilst participating in a trial, you should: Contact your trial coordinator immediately, as trial participants must report adverse events through their study team Report suspected side effects via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk if appropriate Seek urgent medical attention if symptoms are severe Current Availability and Regulatory Status in the UK Neither cagrilintide nor retatrutide holds MHRA marketing authorisation in the UK

Dendrite length was determined using the National Institutes of Health's Image J 1.41o program (NIH, Bethesda, MD) and the neurite tracing program Neuron J (Meijering et al., 2004) Spines were manually counted