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The best studied one is the increase of the VEGF pathway (Vascular Endothelial Growth Factor), indicating the production of new blood vessels (angiogenesis)

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A 26-week diabetes study measured human activity at 1 mg, but its endpoint was blood sugar rather than long-term weight. A short outpatient cohort measured about 4.7% weight loss over four weeks at 2.5 mg. Below 1 mg, estimates rely on pharmacokinetics and mechanism