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J Clin Invest 87:397405 Fountoulakis M, Berndt P, Boelsterli UA, Crameri F, Winter M, Albertini S, Suter L (2000) Two- dimensional database of mouse liver proteins: changes in hepatic protein levels following treatment with acetaminophen or its nontoxic regioisomer 3-acetamidophenol

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In a poor nutritional state, GSH reserves become easily exhausted and hepatic glucouronidation is stunted, leading to decreased levels of available GSH that would otherwise be scavenged for formation of reactive metabolites in phase I of APAP metabolism