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The value of the combo lies in **mechanistic divergence coupled with vascular convergence**: BPC-157 covers local cytoprotection and the gut-tendon axis, TB-500 covers systemic cell migration and stem-cell mobilization, and both converge on the neoangiogenesis required for deep tissue regeneration
Beyond lineage-specific RTKs, broad-spectrum kinase inhibitors such as cabozantinib, erlotinib, sorafenib, and anlotinib exert multifaceted approaches to target MDSC (115118) For example, cabozantinib combined with anti-HER2 immunotherapy reprograms MDSC by suppressing ARG1 and reducing their frequencies (115)
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