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Although conceptual and functional overlap exists, this distinction is important because the two categories are subject to different regulatory pathways and evidentiary requirements

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Metabolomic profiles and associated metadata for the three IBD cohorts were also obtained from published studies and are publicly available as follows: for BushmanFD_2020, data are available on GitHub ( for LloydPriceJ_2019, data are available in the Metabolomics Workbench database under Project ID PR000639

In livestock systems, however, the practical application of GEMs remains extremely limited