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Tesamorelin, a synthetic GHRH analog, that stimulates the synthesis and release of endogenous GH, is the first and, so far, only treatment indicated for the reduction of excess abdominal fat in HIV lipodystrophy (144)

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This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)