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This process serves to regulate the promoterenhancer activity, particularly those involving superenhancers, thereby enhancing the transcription of pluripotencyregulating genes and ultimately supporting the maintenance of pluripotency

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Studies show that high levels of oxidative stress in the body may result in damage to sperm DNA, potentially leading to male infertility and recurrent pregnancy loss

Aged recipients of SIRT3-overexpressing HSCs (T3 Tx) exhibited reduced numbers of CD68 + macrophages, F4/80 + tissue-resident macrophages, and CCR2 high inflammatory monocytes in the tissues, compared to mice transplanted with control HSCs (Cre Tx) (Extended Data Fig