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[41] : 971, 973 Only a few countries, primarily in Africa, have mandatory food fortification programs for either wheat flour or maize flour

For researchers exploring complementary metabolic pathways, compounds like Tesofensine (a monoamine reuptake inhibitor studied for appetite regulation) or MK 677 (a growth hormone secretagogue) address different aspects of energy metabolism and body composition

Unlike vitamin B12 deficiency, which produces well-recognised neurological and haematological manifestations, excess B12 does not typically generate a distinct clinical syndrome

Large national surveys paint a nuanced picture