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Limited intervention studies (highlighted in 8) have not convincingly demonstrated a potential anti-inflammatory effect of -tocopherol in humans

High doses of supplements can also cause side effects, which may include: nausea and vomiting rash blurry vision increased risk of heart disease (if taking folic acid) increased risk of cancer (if taking folic acid) headaches necrotizing enterocolitis (NEC), a life-threatening congenital abnormality Before taking supplements to aid fertility, a person should speak to their doctor about the risks and potential benefits

A., Moye-Rowley, W

Structural and functional differences have since been widely documented