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Individuals with certain medical conditions or allergies should exercise caution

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Interestingly, the expression of PNPLA2 and PNPLA3 oppose one another, with expression of PNPLA2 highest during conditions that promote TAG hydrolysis such as fasting, while the expression of PNPLA3 is highest during conditions that promote TAG synthesis such as feeding (62, 63)

This finding does not establish causality, but it is consistent with a model in which robust mitochondrial peptide signaling is a feature of successful aging rather than a peripheral correlate