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Moreover, active efflux transporters, such as breast cancer resistance protein (BCRP), P-glycoprotein (P-gp), and multidrug resistance-associated proteins (MRPs), expel many therapeutic agents from the endothelial cells back into the bloodstream, significantly reducing their CNS infiltration 69,70

Patients who have reached the point of major surgery will have tried at least one local anesthetic bladder instillation

A mixed model for repeated measurements was used to input any missing data from test subjects that discontinued treatment or required a dose of rescue medication

However, after 40 to 42 weeks, no significant difference in estimated glomerular filtration rate was observed