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Most patients notice the first changes within two weeks: Pain reduction and decreased inflammation come first, followed by improved range of motion and faster recovery as the protocol progresses

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Therefore, considering significance of both NO-system and egr-1 gene-systems for inflammatory bowel disease (54) as well as for multiple sclerosis (55-57), these may be important also when confronted with severe complications of advanced and poorly controlled IBD as well as multiple sclerosis

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