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Why GHK-Cu Works Better Systemically (Not Just Topically) While GHK-Cu is commonly found in serums and post-procedure products, systemic delivery allows it to work beyond the surface of the skin

Researchers observed that the peptides effects were modulated by NOS inhibitors and NO donors, suggesting involvement of the NO-cGMP signaling axis [4]

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However, if the skin barrier is compromised or combined with strong actives, some may experience: Mild stinging, redness, dryness, or temporary tightness Localized heat or tingling after microneedling or chemical peels These are typically temporary