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Description

Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) increases ROS production, and stimulation of FLSs with NOX4 elevates the expression of vascular cell adhesion molecule 1 (VCAM1) and VEGF, contributing to vascular neogenesis and proliferation and migration of FLSs (193)

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These results suggest that damaged cerebral hemodynamics, BBB permeability, and cognitive dysfunction in old diabetic rats are linked to hyperglycemia-triggered cerebrovascular pericyte impairment

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