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Some want long-term wellness

It occurs due to aging, environmental pollution, exposure to tobacco smoke, alcohol, UV radiation, and dozens of other small factors that add up over time

This endogenous production makes glutathione a critical line of defense against oxidative stress, a harmful condition caused by an imbalance between free radicals and antioxidants in the body

In certain embodiments, any controlled release otic formulation or composition described herein increases the exposure of a therapeutic agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition