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[7] When combining GHK-Cu with other scalp prescriptions (e.g., minoxidil or topical retinoids), clinicians may recommend alternating schedules to minimize cumulative irritation, although controlled interaction studies are lacking

For instance, chemical synthesis is used for vitamin b1 and b6, while as, fermentation method is employed to get vitamin b12

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Cartilage & Joint Research Kwon and Park, Annals of Clinical and Laboratory Science (2015) Kwon and Park investigated the chondroprotective effects of intra-articular AOD-9604 administration in a rabbit model of osteoarthritis, with and without co-administration of hyaluronic acid