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While many of the key regulators of this pathway remain largely unknown, recent studies have identified glutathione peroxidases, particularly glutathione peroxidase 4 (GPX4), as antioxidant enzymes that can prevent lipid peroxidation using reduced glutathione (GSH) as a co-factor 9,10

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By focusing on key acupoints (ST36, SP6, and BL23) and rootbranch prescriptions, we integrate molecular pathways (HMGB1/NLRP3/NF-B, SIRT1/PGC-1, eNOS/NO, and autophagy markers) with renal outcomes (proteinuria, Scr, and eGFR)