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We posit that the primordial cysteine is likely to be the cysteine of the CSD which undergoes nucleophilic attack by thioredoxin

[48,49] pointed out that the total glutathione content in the lumen of the endoplasmic reticulum even exceeds the entire cellular glutathione content

doi: 10.1007/s10534-009-9207-6 40 CloonanS

Another interface between the immune system and POMC expression involves Toll-like receptor (most likely TLR4) recognition of lipopolysaccharide, which is a component of the bacterial cell wall