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Nonetheless, hypoxia-induced stabilization of HIF is essential for intestinal homeostasis owing to its regulatory role in the transcription of barrier-protective genes, mucin secretion, antimicrobial peptide synthesis, nucleotide signaling, iron metabolism, and metabolic genes including hexokinase, lactate dehydrogenase, pyruvate kinase, aldolase, phosphofructokinase, and phosphoglycerate kinase, among others 73,80

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The relatively low AUC of 0.64 for patient/carrier comparisons likely reflects overlap in age distribution, with many carriers already within the disease onset window, Supplemental Information Fig

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It helps optimize the activity of immune cells, such as lymphocytes and macrophages, allowing them to combat infections and foreign invaders effectively

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Inhibition of this enzyme can lead to pellagra, which, in these cases, may present with cerebellar signs, myoclonus, and ataxia (55)

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