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Acknowledgements We sincerely thank Ya-Hui Tsai, PhD, research specialist in the Division of Pediatric Surgery, Department of Surgery, Far-Eastern Memorial Hospital for editing the figures in the manuscript

When 3050% are compoundedas is common in menopause-focused practicesits a scaling crisis

The authors concluded that the senescent microenvironment maintained by SASP and p53-pS15 signalling promotes keloid aggressiveness and relapse, and that FOXO4-DRI targets this mechanism selectively